Psoriasis Treatments

Common Psoriasis Treatments

In this section, we’ll cover the most common treatments for psoriasis, including Nopsor’s topical treatment. Nopsor combines essential ingredients with a unique herbal blend to control symptoms without causing rebound effects.

Topical Treatments for Psoriasis

Topical treatments can be used alone or in combination with other therapies and are often chosen based on:

  • Location and Severity: Where and how severe the psoriasis is.
  • Past Responses: Reactions to previous treatments.
  • Risk vs. Benefit and Cost: Balancing effectiveness, safety, and cost.

    When selecting a topical treatment, it’s crucial to consider how it works in the skin, the application method (creams, gels, lotions, shampoos), and the concentration and frequency of use.

    Types of Topical Treatments

    1. Corticosteroids - These synthetic drugs mimic cortisol, a hormone from the adrenal glands. They help reduce inflammation and slow down skin cell production but may have side effects with long-term use, such as skin thinning, stretch marks, and increased risk of infections.
    2. Vitamin D Analogues - These compounds work by regulating skin cell production and inflammation. They include Calcitriol, Tacalcitol, and Calcipotriol. While they are effective for psoriasis, they are typically recommended for controlled use.
    3. Retinoids (Tazarotene) - Tazarotene, a synthetic retinoid, helps reduce skin cell growth and inflammation. However, prolonged use may cause skin irritation and burning, so it’s used in controlled amounts.
    4. Dithranol - Dithranol helps reduce skin cell production and inflammation but is less commonly used due to its unstable nature and lack of standardized formulations.
    5. Tar - Derived from coal, tar has been used for over a century to treat psoriasis. It helps with inflammation and skin cell control and offers lasting effects. However, it may have drawbacks, including staining, odor, and potential skin irritation. Note: Nopsor incorporates coal tar in its formula for lasting results.
    6. Calcineurin Inhibitors - These inhibit T-cell activation in the immune system, reducing inflammation.

      Nopsor Treatment

      Nopsor’s topical formula combines coal tar with a proprietary herbal blend designed to manage psoriasis symptoms effectively without rebound effects, making it suitable for long-term use.

      Biological Treatments for Psoriasis

      Biological treatments, or biologics, are derived from natural sources like human or animal cells and target specific parts of the immune system that contribute to psoriasis. These treatments are often used for moderate-to-severe psoriasis when other therapies are insufficient. Here’s a breakdown of some common types:

      1. TNF-alpha Inhibitors
        These drugs block the tumor necrosis factor-alpha (TNF-alpha) protein, which plays a key role in causing inflammation in psoriasis.

        • Examples: Etanercept (Enbrel), Infliximab (Remicade), Adalimumab (Humira)

      2. IL-17 Inhibitors
        IL-17 inhibitors block the IL-17 protein, significantly reducing inflammation and overproduction of skin cells.

        • Examples: Secukinumab (Cosentyx), Ixekizumab (Taltz), Brodalumab (Siliq)

      3. IL-23 Inhibitors
        By targeting IL-23, these treatments help decrease immune response and control inflammation.

        • Examples: Guselkumab (Tremfya), Tildrakizumab (Ilumya), Risankizumab (Skyrizi)

      4. IL-12/23 Inhibitors
        These biologics target both IL-12 and IL-23 proteins, reducing inflammation and immune activity.

        • Example: Ustekinumab (Stelara)

      5. JAK Inhibitors
        Although not a traditional biologic, JAK inhibitors are oral medications that interfere with Janus kinase pathways involved in immune response.

        • Examples: Tofacitinib (Xeljanz), Baricitinib (Olumiant)

      6. PDE4 Inhibitors (Apremilast)
        Apremilast (Otezla) is an oral medication that inhibits phosphodiesterase 4 (PDE4), reducing inflammation. It’s commonly used for psoriatic arthritis and plaque psoriasis.

      7. Traditional Immunosuppressants (Methotrexate and Cyclosporine)
        These drugs suppress the immune system to control inflammation and are sometimes used when biologics aren’t suitable.

      Risks of Biological Treatments

      Biologics are powerful and effective, but they come with risks, including:

      • Higher susceptibility to respiratory and skin infections
      • Possible reactivation of latent infections, like tuberculosis

      Biologics are tailored treatments, and the choice depends on individual factors such as health history, treatment goals, and the severity of psoriasis.